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Development and Validation of a Nomogram Based on CA125 Levels for Predicting Progression-free Survival in Patients with Ovarian Cancer by Minjun He; Hongyu Peng; Zhifeng Liu; Quanyang Gao is a scholarly article available to read on EtoBox.

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## Abstract Background Ovarian cancer is the leading cause of death in patients with gynecological cancers, and it has very low survival. CA125 have been shown to be an important prognostic factor for PFS, Therefore, we aimed to develop and validate a nomogram incorporating CA125 levels after three cycles of chemotherapy for predicting progression-free survival (PFS) in patients with ovarian cancer.Methods The nomogram was developed in a primary cohort of 491 patients with stage II-IV ovarian cancer. Performance was assessed by concordance index (C-index), calibration curve, and decision curve analysis, and compared with the International Federation of Gynecology and Obstetrics (FIGO) staging system. The predictive value of CA125 levels after three cycles of chemotherapy was evaluated. The model was subjected to bootstrap internal validation. An independent cohort of 81 patients was used for external validation.Results CA125 levels after three cycles of chemotherapy were significantly associated with PFS. Five variables, including CA125 levels were selected to develop the nomogram. The nomogram demonstrated adequate discrimination, with a bootstrap-corrected C-index of 0.708, and g

Author

Minjun He; Hongyu Peng; Zhifeng Liu; Quanyang Gao

Publisher

Research Square Platform LLC

Published

2021

Language

EN