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Number needed to vaccinate with a COVID-19 booster to prevent a COVID-19-associated hospitalization during SARS-CoV-2 Omicron BA.1 variant predominance, December 2021–February 2022, VISION Network: a retrospective cohort study by Katherine Adams; John J. Riddles; Elizabeth A.K. Rowley; Shaun J. Grannis; Manjusha Gaglani; Bruce Fireman; Emily Hartmann; Allison L. Naleway; Edward Stenehjem; Alexandria Hughes; Alexandra F. Dalton; Karthik Natarajan; Kristin Dascomb; Chandni Raiyani; Stephanie A. Irving; Chantel Sloan-Aagard; Anupam B. Kharbanda; Malini B. DeSilva; Brian E. Dixon; Toan C. Ong; Jean Keller; Monica Dickerson; Nancy Grisel; Kempapura Murthy; Juan Nanez; William F. Fadel; Sarah W. Ball; Palak Patel; Julie Arndorfer; Mufaddal Mamawala; Nimish R. Valvi; Margaret M. Dunne; Eric P. Griggs; Peter J. Embi; Mark G. Thompson; Ruth Link-Gelles; Mark W. Tenforde is a Medicine article available to read on EtoBox.

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## Summary ## Background Understanding the usefulness of additional COVID-19 vaccine doses—particularly given varying disease incidence—is needed to support public health policy. We characterize the benefits of COVID-19 booster doses using number needed to vaccinate (NNV) to prevent one COVID-19-associated hospitalization or emergency department encounter. ## Methods We conducted a retrospective cohort study of immunocompetent adults at five health systems in four U.S. states during SARS-CoV-2 Omicron BA.1 predominance (December 2021–February 2022). Included patients completed a primary mRNA COVID-19 vaccine series and were either eligible to or received a booster dose. NNV were estimated using hazard ratios for each outcome (hospitalization and emergency department encounters), with results stratified by three 25-day periods and site. ## Findings 1,285,032 patients contributed 938 hospitalizations and 2076 emergency department encounters. 555,729 (43.2%) patients were aged 18–49 years, 363,299 (28.3%) 50–64 years, and 366,004 (28.5%) ≥65 years. Most patients were female (n = 765,728, 59.6%), White (n = 990,224, 77.1%), and non-Hispanic (n = 1,063,964, 82.8%). 37.2% of patients rec

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Author

Katherine Adams; John J. Riddles; Elizabeth A.K. Rowley; Shaun J. Grannis; Manjusha Gaglani; Bruce Fireman; Emily Hartmann; Allison L. Naleway; Edward Stenehjem; Alexandria Hughes; Alexandra F. Dalton; Karthik Natarajan; Kristin Dascomb; Chandni Raiyani; Stephanie A. Irving; Chantel Sloan-Aagard; Anupam B. Kharbanda; Malini B. DeSilva; Brian E. Dixon; Toan C. Ong; Jean Keller; Monica Dickerson; Nancy Grisel; Kempapura Murthy; Juan Nanez; William F. Fadel; Sarah W. Ball; Palak Patel; Julie Arndorfer; Mufaddal Mamawala; Nimish R. Valvi; Margaret M. Dunne; Eric P. Griggs; Peter J. Embi; Mark G. Thompson; Ruth Link-Gelles; Mark W. Tenforde

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)