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Rapamycin Mitigates Cataracts in Zebrafish by itsjohndoe7741 is a document available to read on EtoBox.
The study investigates the role of autophagy in cataract formation in zebrafish caused by the ablation of the Gja8b gene, a homolog of the human GJA8 gene associated with cataracts. It was found that rapamycin, an autophagy activator, alleviated cataract symptoms by stimulating autophagy and improving organelle degradation in the lens of Gja8b mutant zebrafish. The findings suggest a potential therapeutic approach for cataracts through autophagy modulation.
- Author
- itsjohndoe7741
- Language
- EN