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Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine by P.T. Heath, E.P. Galiza, D.N. Baxter, M. Boffito, D. Browne, F. Burns, D.R. Chadwick, R. Clark, C. Cosgrove, J. Galloway, A.L. Goodman, A. Heer, A. Higham, S. Iyengar, A. Jamal, C. Jeanes, P.A. Kalra, C. Kyriakidou is a nonfiction available to read on EtoBox.

What is Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine about?

BACKGROUNDEarly clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recom-binant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) that contains the full-length spike glycoprotein of the prototypestrain plus Matrix-M adjuvant, showed that the vaccine was safe and associatedwith a robust immune response in healthy adult participants. Additional data wereneeded regarding the efficacy, immunogenicity, and safety of this vaccine in alarger population.METHODSIn this phase 3, randomized, observer-blinded, placebo-controlled trial conductedat 33 sites in the United Kingdom, we assigned adults between the ages of 18 and84 years in a 1:1 ratio to receive two intramuscular 5-μg doses of NVX-CoV2373or placebo administered 21 days apart. The primary efficacy end point was viro-logically confirmed mild, moderate, or severe SARS-CoV-2 infection with an onsetat least 7 days after the second injection in participants who were serologicallynegative at baseline.RESULTSA total of 15,187 participants underwent randomization, and 14,039 were includedin the per-protocol efficacy population. Of the participants, 27.9% were 65 yearsof age or older, and

Who reads Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine?

Author

P.T. Heath, E.P. Galiza, D.N. Baxter, M. Boffito, D. Browne, F. Burns, D.R. Chadwick, R. Clark, C. Cosgrove, J. Galloway, A.L. Goodman, A. Heer, A. Higham, S. Iyengar, A. Jamal, C. Jeanes, P.A. Kalra, C. Kyriakidou

Publisher

The New England Journal of Medicine

Published

2021

Language

EN

Category

nonfiction

Subjects

Science, Virology, Stem