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Glomerular barrier dysfunction in glomerulosclerosis‐ resistant Milan rats with experimental diabetes: the role of renal haemodynamics by G Pugliese; C Ricci; C Iacobini; S Menini; P Fioretto; M Ferrandi; LA Giardino; S Armelloni; D Mattinzoli; MP Rastaldi; F Pugliese is a Medicine article available to read on EtoBox.

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## Abstract Rats of the Milan hypertensive strain (MHS) are resistant to both hypertensive and diabetic renal disease. Genetically determined hypertrophy of intrarenal arteries has been suggested as the putative mechanism preventing transmission of systemic hypertension to the glomerular microcirculation or diabetes‐induced loss of autoregulation, which lead to glomerular hypertension and consequent podocyte injury and proteinuria. This study aimed to investigate glomerular barrier function and structure in ageing and diabetic MHS rats under basal conditions and after injection of 2.5 g of bovine serum albumin (BSA) causing increased workload and possibly removing haemodynamic protection by inducing renal cortical vasodilatation. Genetically related rats of the Milan normotensive strain (MNS) served as a proteinuric counterpart. No change in renal function or structure was detected in diabetic MHS rats, whereas MNS rats developed diabetic nephropathy superimposed on that occurring spontaneously in this strain. Diabetic, but not non‐diabetic, MHS rats showed significantly reduced synaptopodin and nephrin expression, though to a lesser extent than non‐diabetic and diabetic MNS rats,

Who reads Glomerular barrier dysfunction in glomerulosclerosis‐ resistant Milan rats with experimental diabetes: the role of renal haemodynamics?

Author

G Pugliese; C Ricci; C Iacobini; S Menini; P Fioretto; M Ferrandi; LA Giardino; S Armelloni; D Mattinzoli; MP Rastaldi; F Pugliese

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2007

Language

EN

Field

Medicine (Health Sciences)