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Can I read Nuclear Magnetic Resonance and Molecular Modeling Analysis of the Interaction of the Antimalarial Drugs Artelinic Acid and Artesunic Acid with Beta-cyclodextrin on EtoBox?
Nuclear Magnetic Resonance and Molecular Modeling Analysis of the Interaction of the Antimalarial Drugs Artelinic Acid and Artesunic Acid with Beta-cyclodextrin by Mark G. Hartell; Rickey Hicks; Apurba K. Bhattacharjee; Brandon W. Koser; Keith Carvalho; John E. Van Hamont is a Chemistry article available to read on EtoBox.
What is Nuclear Magnetic Resonance and Molecular Modeling Analysis of the Interaction of the Antimalarial Drugs Artelinic Acid and Artesunic Acid with Beta-cyclodextrin about?
The artemisinin derivatives artelinic acid and artesunic acid are members of a class of compounds that have shown promise for the treatment of multidrug resistant strains of Plasmodium falciparum. Unfortunately, these compounds exhibit poor solubility and stability in aqueous solution. The research presented herein was conducted to determine whether complexation of artelinic acid or artesunic acid with beta-cyclodextrin would result in complexes with increased aqueous solubility while retaining the potent antimalarial activity of these compounds. Preliminary complexation studies with natural beta-cyclodextrins were conducted as a proof of concept, with a primary focus on understanding the electrostatic interactions that stabilize the resulting complexes. Complex formation was monitored using UV spectroscopy. The structures of the resulting complexes were determined using multidimensional nuclear magnetic resonance spectroscopy (NMR) and molecular modeling. NMR results are most consistent for artelinic acid and beta-cyclodextrin forming complexes in a ratio of 2:1; however, the presence of 1:1, 2:2, and 3:1 complexes in solution cannot be excluded based on the experimental data coll
Who reads Nuclear Magnetic Resonance and Molecular Modeling Analysis of the Interaction of the Antimalarial Drugs Artelinic Acid and Artesunic Acid with Beta-cyclodextrin?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Mark G. Hartell; Rickey Hicks; Apurba K. Bhattacharjee; Brandon W. Koser; Keith Carvalho; John E. Van Hamont
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2004
- Language
- EN
- Field
- Chemistry (Physical Sciences)