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Can I read P20-8 The impact of valproic acid on overall survival in patients with glioblastoma: A systematic review and meta-analysis on EtoBox?
P20-8 The impact of valproic acid on overall survival in patients with glioblastoma: A systematic review and meta-analysis by Charlotte A. Jonatan; Elizabeth Marcella; Jeannette Tandiono; Sharon Chen; Felix Wijovi; Andree Kurniawan; Petra OP. Wahjoepromono is a Medicine article available to read on EtoBox.
What is P20-8 The impact of valproic acid on overall survival in patients with glioblastoma: A systematic review and meta-analysis about?
Background: Concurrent chemoradiotherapy (CCRT) with cisplatin (CDDP) is a standard treatment for locally advanced head and neck cancer (LAHNC) in the adjuvant setting. Three cycles of 100 mg/m2 CDDP for every three weeks (Q3W) are recommended. However, compliance is relatively low due to its toxicity. Thus, the triweekly CDDP 80 mg/m2 Q3W regimen was compared with the 100 mg/m2 regimen in this study. Methods: Patients with LAHNC who underwent adjuvant CCRT with CDDP between 2012 and 2018 at The Cancer Institute Hospital of JFCR were retrospectively analyzed. Patients were classified into two groups based on the planned CDDP dose: (A) 100 mg/m2 and (B) 80 mg/m2 Q3W for three times. Overall survival (OS) and recurrencefree survival (RFS) were compared by the Kaplan-Meier method. The Cox proportional hazards model was adopted to identify prognostic factors. The dose and density of CDDP and the objective adverse events were evaluated.
Who reads P20-8 The impact of valproic acid on overall survival in patients with glioblastoma: A systematic review and meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Charlotte A. Jonatan; Elizabeth Marcella; Jeannette Tandiono; Sharon Chen; Felix Wijovi; Andree Kurniawan; Petra OP. Wahjoepromono
- Publisher
- Elsevier BV
- Published
- 2021
- Field
- Medicine (Health Sciences)