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Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium by Sara L. Crockett; Eva-Maria Wenzig; Olaf Kunert; Rudolf Bauer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium about?

Phytochemical investigation of Hypericum empetrifolium Willd. (Clusiaceae), a species native to Greece and Turkey has led to the bioassayguided identification of two acylphloroglucinol derivatives with potent in vitro anti-inflammatory activity. Using NMR spectroscopy and mass spectrometry, the acylphloroglucinol derivatives were characterized as 3-geranyl-1-(2 0 -methylpropanoyl)phloroglucinol (1) and 3-geranyl-1-(2 0methylbutanoyl)phloroglucinol (2). Hypotheses are proposed regarding the biosynthetic origin of these and similar acylphloroglucinols from related Hypericum species. Compounds 1 and 2 were evaluated for in vitro inhibitory activity against COX-1, COX-2 and 5-LOX catalyzed LTB 4 formation. Compound 1 displayed good activity (IC 50 values: 6.0, 29.9, and 2.2 mM, respectively) in all three assays. Compound 2 showed good activity (IC 50 value: 5.8 mM) against LTB 4 formation and moderate activity (IC 50 value: 26.2 mM) against COX-1.

Who reads Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium?

Author

Sara L. Crockett; Eva-Maria Wenzig; Olaf Kunert; Rudolf Bauer

Publisher

Elsevier ; Elsevier BV (ISSN 1874-3900)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)