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Static and Dynamic Mechanics of the Murine Lung After Intratracheal Bleomycin by Effrosyni D Manali; Charalampos Moschos; Christina Triantafillidou; Anastasia Kotanidou; Ioannis Psallidas; Sophia P Karabela; Charis Roussos; Spyridon Papiris; Apostolos Armaganidis; Georgios T Stathopoulos; Nikolaos A Maniatis is a Medicine article available to read on EtoBox.

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## Background Despite its widespread use in pulmonary fibrosis research, the bleomycin mouse model has not been thoroughly validated from a pulmonary functional standpoint using new technologies. Purpose of this study was to systematically assess the functional alterations induced in murine lungs by fibrogenic agent bleomycin and to compare the forced oscillation technique with quasi-static pressure-volume curves in mice following bleomycin exposure. ## Methods Single intratracheal injections of saline (50 μL) or bleomycin (2 mg/Kg in 50 μL saline) were administered to C57BL/6 (__n__ = 40) and Balb/c (__n__ = 32) mice. Injury/fibrosis score, tissue volume density (TVD), collagen content, airway resistance (__R~N~__), tissue damping (__G__) and elastance coefficient (__H__), hysteresivity (__η__), and area of pressure-volume curve (PV-A) were determined after 7 and 21 days (inflammation and fibrosis stage, respectively). Statistical hypothesis testing was performed using one-way ANOVA with LSD __post hoc__ tests. ## Results Both C57BL/6 and Balb/c mice developed weight loss and lung inflammation after bleomycin. However, only C57BL/6 mice displayed cachexia and fibrosis, evidenced b

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Author

Effrosyni D Manali; Charalampos Moschos; Christina Triantafillidou; Anastasia Kotanidou; Ioannis Psallidas; Sophia P Karabela; Charis Roussos; Spyridon Papiris; Apostolos Armaganidis; Georgios T Stathopoulos; Nikolaos A Maniatis

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2466)

Published

2011

Language

EN

Field

Medicine (Health Sciences)