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Synthesis of [^76^Br]4‐bromodexetimide and [^76^Br]4‐bromolevetimide: Radiotracers for studying muscarinic cholinergic receptors using PET by Michael Kassiou; Christian Loc'h; Veronique Strijckmans; Andrew Katsifis; Richard M. Lambrecht; Mariannick Maziere; Bernard Maziere is a Chemistry article available to read on EtoBox.
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## Abstract The muscarinic cholinergic receptor antagonist dexetimide and its pharmacologically inactive enantiomer levetimide were labelled with the positron emitter bromine‐76. [^76^Br]4‐Bromodexetide, [^76^Br]BrDEX, and [^76^Br]4‐bromolevetimide, [^76^]BrLEV, were prepared via electrophilic bromodesilylation of 4‐(trimethylsilyl)dexetimide and 4‐(trimethyylsilyl)levetimide with [^76^Br]NH~4~. The use of chloramine‐T in acid media resulted in radiochemical yields of 80%. The radiotracers were purified by semi‐preparative reverse‐phase HPLC. Radiochemical and chemical purities were assessed by radio‐TLC and HPLC and found to be 98%. The average time of synthesis including formulation was 60 minutes resulting in average specific activities of 300 mCi/μmol.
Who reads Synthesis of [^76^Br]4‐bromodexetimide and [^76^Br]4‐bromolevetimide: Radiotracers for studying muscarinic cholinergic receptors using PET?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Michael Kassiou; Christian Loc'h; Veronique Strijckmans; Andrew Katsifis; Richard M. Lambrecht; Mariannick Maziere; Bernard Maziere
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)
- Published
- 1995
- Language
- EN
- Field
- Chemistry (Life Sciences)