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Finite Element Study of Stem Cells Under Fluid Flow for Mechanoregulation Toward Osteochondral Cells by Mehdi Moradkhani; Bahman Vahidi; Bahram Ahmadian is a Engineering article available to read on EtoBox.

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Investigating the effects of mechanical stimuli on stem cells under in vitro and in vivo conditions is a very important issue to reach better control on cellular responses like growth, proliferation, and differentiation. In this regard, studying the effects of scaffold geometry, steady, and transient fluid flow, as well as influence of different locations of the cells lodged on the scaffold on effective mechanical stimulations of the stem cells are of the main goals of this study. For this purpose, collagen-based scaffolds and implicit surfaces of the pore architecture was used. In this study, computational fluid dynamics and fluid-structure interaction method was used for the computational simulation. The results showed that the scaffold microstructure and the pore architecture had an essential effect on accessibility of the fluid to different portions of the scaffold. This leads to the optimization of shear stress and hydrodynamic pressure in different surfaces of the scaffold for better transportation of oxygen and growth factors as well as for optimized mechanoregulative responses of cell–scaffold interactions. Furthermore, the results indicated that the HP scaffold provides mo

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Author

Mehdi Moradkhani; Bahman Vahidi; Bahram Ahmadian

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Engineering (Physical Sciences)