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Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy by Nishino, Seiji; Sakurai, Takeshi is a scholarly article available to read on EtoBox.

What is Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy about?

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/H

Author

Nishino, Seiji; Sakurai, Takeshi

Publisher

Humana Press

Published

2005

Language

EN

ISBN

9781617375743