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Improved Pharmacokinetics of Sumatriptan With Breath PoweredTM Nasal Delivery of Sumatriptan Powder by Mohammad Obaidi; Elliot Offman; John Messina; Jennifer Carothers; Per G. Djupesland; Ramy A. Mahmoud is a Medicine article available to read on EtoBox.
What is Improved Pharmacokinetics of Sumatriptan With Breath PoweredTM Nasal Delivery of Sumatriptan Powder about?
## Objectives.— The purpose of this study was to directly compare the pharmacokinetic (PK) profile of 22-mg sumatriptan powder delivered intranasally with a novel Breath PoweredTM device (11 mg in each nostril) vs a 20-mg sumatriptan liquid nasal spray, a 100-mg oral tablet, and a 6-mg subcutaneous injection. ## Background.— A prior PK study found that low doses of sumatriptan powder delivered intranasally with a Breath Powered device were efficiently and rapidly absorbed. An early phase clinical trial with the same device and doses found excellent tolerability with high response rates and rapid onset of pain relief, approaching the benefits of injection despite significantly lower predicted drug levels. ## Methods.— An open-label, cross-over, comparative bioavailability study was conducted in 20 healthy subjects at a single center in the USA. Following randomization, fasted subjects received a single dose of each of the 4 treatments separated by a 7-day washout. Blood samples were taken pre-dose and serially over 14 hours post-dose for PK analysis. ## Results.— Quantitative measurement of residuals in used Breath Powered devices demonstrated that the devices delivered 8 ± 0.9 mg (
Who reads Improved Pharmacokinetics of Sumatriptan With Breath PoweredTM Nasal Delivery of Sumatriptan Powder?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mohammad Obaidi; Elliot Offman; John Messina; Jennifer Carothers; Per G. Djupesland; Ramy A. Mahmoud
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0017-8748)
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)