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Microimaging of hairless rat skin by magnetic resonance at 900 MHz by Rakesh Sharma is a Medicine article available to read on EtoBox.

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## Purpose: Quantitative imaging of the rat skin was performed using magnetic resonance imaging (mri) at 900 mhz. ## Materials and methods: A number of imaging techniques utilized for multiple contrast included magnetization transfer contrast, spin-lattice relaxation constant (t1-weighting), combination of t2-weighting with magnetic field inhomogeneity (t2\*-weighting), magnetization transfer weighting and diffusion tensor weighting. these were used to obtain 2d slices and 3d multislice-multiecho images with high magnetic resonance contrast. these 2d and 3d imaging techniques were combined to achieve high-resolution mri. ## Results: Oil-water phantom showed distinct fat-water contrast. the dermis and epidermis, including the stratum corneum remnants, of nude rat skin were distinct due to their proton magnetic resonance as a result of proton interactions with the skin interstitial tissue. combined details obtained from high-resolution, high-quality ex vivo skin images with different multicontrast characteristics generated better differentiation of skin layers, sublayers and significant correlation (r(2)=0.4927 for mri area, r(2)=0.3068 for histology area; p<.0148) of mr data with co

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Author

Rakesh Sharma

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)

Published

2009

Language

EN

Field

Medicine (Health Sciences)