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Antiviral Prophylaxis During Pandemic Influenza May Increase Drug Resistance by Martin Eichner; Markus Schwehm; Hans-Peter Duerr; Mark Witschi; Daniel Koch; Stefan O Brockmann; Beatriz Vidondo is a Medicine article available to read on EtoBox.

What is Antiviral Prophylaxis During Pandemic Influenza May Increase Drug Resistance about?

## Background: Neuraminidase inhibitors (ni) and social distancing play a major role in plans to mitigate future influenza pandemics. ## Methods: Using the freely available program influsim, the authors examine to what extent ni-treatment and prophylaxis promote the occurrence and transmission of a ni resistant strain. ## Results: Under a basic reproduction number of r0 = 2.5, a ni resistant strain can only spread if its transmissibility (fitness) is at least 40% of the fitness of the drug-sensitive strain. although ni drug resistance may emerge in treated patients in such a late state of their disease that passing on the newly developed resistant viruses is unlikely, resistant strains quickly become highly prevalent in the population if their fitness is high. antiviral prophylaxis further increases the pressure on the drug-sensitive strain and favors the spread of resistant infections. the authors show scenarios where pre-exposure antiviral prophylaxis even increases the number of influenza cases and deaths. ## Conclusion: If the fitness of a ni resistant pandemic strain is high, any use of prophylaxis may increase the number of hospitalizations and deaths in the population. the u

Who reads Antiviral Prophylaxis During Pandemic Influenza May Increase Drug Resistance?

Author

Martin Eichner; Markus Schwehm; Hans-Peter Duerr; Mark Witschi; Daniel Koch; Stefan O Brockmann; Beatriz Vidondo

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)

Published

2009

Language

EN

Field

Medicine (Health Sciences)