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Two Potentially Distinct Pathways to Geographic Atrophy in Age-related Macular Degeneration Characterized by Quantitative Fundus Autofluorescence by Wei Wei; Marco Mazzola; Oscar Otero-Marquez; Yuehong Tong; Eric Souied; Giuseppe Querques; K. Bailey Freund; R. Theodore Smith is a Medicine article available to read on EtoBox.
What is Two Potentially Distinct Pathways to Geographic Atrophy in Age-related Macular Degeneration Characterized by Quantitative Fundus Autofluorescence about?
BACKGROUND/AIMS: To demonstrate two distinct pathways to geographic atrophy (GA) that originate from soft drusen/ pigment epithelial detachments (PEDs) and subretinal drusenoid deposits (SDDs), respectively, and are characterized by their final quantitative autofluorescence (qAF) levels. METHODS: 23 eyes of 18 patients with GA underwent spectral-domain optical coherence tomography (SD-OCT) and qAF imaging on the qAF-ready Heidelberg Spectralis. 52 GA Regions-of-interest (ROIs), or clusters of adjacent lesions, were selected, and the ROIs were divided into groups by the dominant iAMD precursors on prior serial tracked SD-OCT scans. Mean qAF values and structural SD-OCT findings of groups were compared. RESULTS: Group 1 lesions (soft drusen/PED precursors, 18/52) were isolated, with lower mean qAF (35.88 ± 12.75 units); group 3 lesions (SDD precursors, 12/52) were multilobular, with significantly higher mean qAF (71.62 ± 12.12 units, p < 0.05). Group 2 lesions, (mixed precursors, 22/52) had intermediate mean qAF (58.13 ± 67.92 units). Significantly greater prevalence of split RPE/ Bruch's membrane complex in SDD-associated GA, suggesting basal laminar deposit (BLamD), than in drusen-
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- Author
- Wei Wei; Marco Mazzola; Oscar Otero-Marquez; Yuehong Tong; Eric Souied; Giuseppe Querques; K. Bailey Freund; R. Theodore Smith
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)