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Parathyroid carcinoma in more than 1,000 patients: A population-level analysis by Claire Sadler; Kenneth W. Gow; Elizabeth A. Beierle; John J. Doski; Monica Langer; Jed G. Nuchtern; Sanjeev A. Vasudevan; Melanie Goldfarb is a Medicine article available to read on EtoBox.

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## Background: Parathyroid carcinoma (pc) is a rare malignancy with a moderate prognosis. the staging system, prognostic indicators, and optimal surgical management are still under debate. this large cohort explores prognostic factors for pc. ## Methods: 1,022 cases of pc in the 1998-2011 national cancer data base that underwent surgery were examined for predictors of lower overall survival (os) and relative risk (rr) of death at 5 years. ## Results: The 5-year os was 81.1% in 528 patients with ≥ 60 months of follow-up. the overall cohort was mainly non-hispanic (96.5%), white (77.4%), and insured (94.3%), with a median age of 57 years. mean os was lower and rr of death greater in older (p < .001), black (p = .007) patients with a secondary malignancy (p = .015) and ≥ 2 comorbidities (p = .005), whose surgical specimen had positive surgical margins (p = .026) or positive lymph nodes (p < .001). multivariate cox regression demonstrated that positive lymph nodes (hazard ratio [hr], 6.47; 95% ci, 1.81-23.11) and older age (hr, 2.35; 95% ci, 1.25-4.43) were associated with lower os. ## Conclusion: Pc is a rare malignancy with a 5-year os of 81.1%. positive lymph nodes and older age pre

Who reads Parathyroid carcinoma in more than 1,000 patients: A population-level analysis?

Author

Claire Sadler; Kenneth W. Gow; Elizabeth A. Beierle; John J. Doski; Monica Langer; Jed G. Nuchtern; Sanjeev A. Vasudevan; Melanie Goldfarb

Publisher

Elsevier BV

Published

2014

Language

EN

Field

Medicine (Health Sciences)