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Haematological manifestations of Sjögren’s syndrome by Su-Ann Yeoh; Coziana Ciurtin is a book available to read on EtoBox.

What is Haematological manifestations of Sjögren’s syndrome about?

Haematological abnormalities in primary Sjögren’s syndrome (pSS) may present in various ways—anaemia (the most frequently occurring cytopoenia), leucopoenia (lymphopoenia or neutropoenia), thrombocytopoenia, hypergammaglobulinaemia, or hypocomplementaemia—all of which can occur either in isolation or in combination. They occur more commonly in patients with positive anti-Ro/SSA status and can occur even before sicca symptoms appear. Patients with pSS have an increased risk of developing non-Hodgkin’s lymphoma, with mucosa-associated lymphoid tissue non-Hodgkin’s lymphoma of the salivary glands being the most common. Adverse haematological prognostic factors include hypocomplementaemia, hypergammaglobulinaemia, and cryoglobulinaemia. In this review, we also discuss therapeutics used in pSS treatment and their effect on haematological abnormalities.

Author

Su-Ann Yeoh; Coziana Ciurtin

Publisher

Oxford University Press

Published

2021

Language

EN