About this Medicine article

Evaluating the Safety and Dosing of Drugs in Patients with Liver Cirrhosis by Literature Review and Expert Opinion by Rianne A Weersink; Margriet Bouma; David M Burger; Joost P H Drenth; Nicole G M Hunfeld; Minke Kranenborg; Margje H Monster-Simons; Sandra A W van Putten; Herold J Metselaar; Katja Taxis; Sander D Borgsteede is a Medicine article available to read on EtoBox.

## Introduction Liver cirrhosis can have a major impact on drug pharmacokinetics and pharmacodynamics. Patients with cirrhosis often suffer from potentially preventable adverse drug reactions. Guidelines on safe prescribing for these patients are lacking. The aim of this study is to develop a systematic method for evaluating the safety and optimal dosage of drugs in patients with liver cirrhosis. ## Methods and analysis For each drug, a six-step evaluation process will be followed. (1) Available evidence on the pharmacokinetics and safety of a drug in patients with liver cirrhosis will be collected from the Summary of Product Characteristics (SmPC) and a systematic literature review will be performed. (2) Data regarding two outcomes, namely pharmacokinetics and safety, will be extracted and presented in a standardised assessment report. (3) A safety classification and dosage suggestion will be proposed for each drug. (4) An expert panel will discuss the validity and clinical relevance of this suggested advice. (5) Advices will be implemented in all relevant Clinical Decision Support Systems in the Netherlands and published on a website for patients and healthcare professionals. (6)

Author

Rianne A Weersink; Margriet Bouma; David M Burger; Joost P H Drenth; Nicole G M Hunfeld; Minke Kranenborg; Margje H Monster-Simons; Sandra A W van Putten; Herold J Metselaar; Katja Taxis; Sander D Borgsteede

Publisher

BMJ

Published

2016

Language

EN

Field

Medicine (Health Sciences)