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The “Super-Child” Approach Is Applied To Estimate Retinol Kinetics and Vitamin A Total Body Stores in Mexican Preschoolers by Lopez-Teros, Veronica; Ford, Jennifer L; Green, Michael H; Monreal-Barraza, Brianda; García-Miranda, Lilian; Tanumihardjo, Sherry A; Valencia, Mauro E; Astiazaran-Garcia, Humberto is a Medicine article available to read on EtoBox.
What is The “Super-Child” Approach Is Applied To Estimate Retinol Kinetics and Vitamin A Total Body Stores in Mexican Preschoolers about?
## Background: Retinol isotope dilution (rid) and model-based compartmental analysis are recognized techniques for assessing vitamin a (va) status. recent studies have shown that rid predictions of va total body stores (tbs) can be improved by using modeling and that va kinetics and tbs in children can be effectively studied by applying population modeling ("super-child" approach) to a composite data set. ## Objectives: The objectives were to model whole-body retinol kinetics and predict va tbs in a group of mexican preschoolers using the super-child approach and to use model predictions of rid coefficients to estimate tbs by rid in individuals. ## Methods: Twenty-four healthy mexican children (aged 3-6 y) received an oral dose (2.96 μmol) of [13c10]retinyl acetate in corn oil. blood samples were collected from 8 h to 21 d after dosing, with each child sampled at 4 d and at 1 other time. composite data for plasma labeled retinol compared with time were analyzed using a 6-component model to obtain group retinol kinetic parameters and pool sizes. model-predicted tbs was compared with mean rid predictions at 4 d; rid estimates at 4 d were compared with those calculated at 7-21 d. ## R
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- Author
- Lopez-Teros, Veronica; Ford, Jennifer L; Green, Michael H; Monreal-Barraza, Brianda; García-Miranda, Lilian; Tanumihardjo, Sherry A; Valencia, Mauro E; Astiazaran-Garcia, Humberto
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)