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Can I read Targeting Feedback Activation of Signaling Transduction Pathways to Overcome Drug Resistance in Cancer on EtoBox?
Targeting Feedback Activation of Signaling Transduction Pathways to Overcome Drug Resistance in Cancer by Xuejian Wang; Wenyan Jiang; Yanmei Du; Dongqi Zhu; Jian Zhang; Chunyan Fang; Fang Yan; Zhe-Sheng Chen is a Medicine article available to read on EtoBox.
What is Targeting Feedback Activation of Signaling Transduction Pathways to Overcome Drug Resistance in Cancer about?
Dysregulation or aberrant signaling transduction contributes to tumorigenesis. Targeting these abnormal signaling pathways becomes an effective anticancer strategy. However, feedback activation or crosstalk between signaling pathways drives adaptive drug resistance which causes failure of cancer therapy. In this review article, we summarized treatments that cause feedback activation of AKT, ERK, STAT3, EGFR, FGFR, and HER2/3 signaling pathways and the combination therapy to enhance anti-tumor effect or to overcome drug resistance, to explore the underlying mechanisms that define the protein molecules participated or regulated the feedback activation. In addition, we reviewed clinical trials that employ combination treatments to suppress feedback activation and improve therapeutic efficacy of cancer treatments.
Who reads Targeting Feedback Activation of Signaling Transduction Pathways to Overcome Drug Resistance in Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Xuejian Wang; Wenyan Jiang; Yanmei Du; Dongqi Zhu; Jian Zhang; Chunyan Fang; Fang Yan; Zhe-Sheng Chen
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)