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Identification of differentially expressed genes in T-lymphoid malignancies in an animal model system by Cindi R. Starkey; Laura S. Levy is a Medicine article available to read on EtoBox.

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## Abstract The molecular events characterizing lymphoid malignancy have been examined in an animal model system, specifically, the retroviral induction of leukemia and lymphoma in the domestic cat following infection with feline leukemia virus (FeLV). Genes differentially expressed in FeLV‐induced lymphomas were isolated using a strategy of differential hybridization. Six genes were identified which demonstrate a higher level of expression in an FeLV‐induced feline thymic tumor as compared with normal thymus. The differentially expressed genes encode the feline homologues of ribosomal proteins S3a, S4, S17, and L41, elongation factor‐1α, and cytochrome oxidase sub‐unit 1. Northern‐blot analysis and quantification by phosphorimaging demonstrates that these genes are expressed at levels from 1.5‐to 3.1‐fold higher in J5–1 thymic tumor as compared with normal thymus. Expression of the selected ribosomal protein mRNA was further examined in a series of human and feline tissues, including normal tissues, malignant tumors and cell lines. Our data reveal that elevation of the selected ribosomal protein mRNA is associated with all FeLV‐induced thymic lymphomas examined. The differentially

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Author

Cindi R. Starkey; Laura S. Levy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1995

Language

EN

Field

Medicine (Health Sciences)