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Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus by Casavilla, F. Adrian ;Rakela, Jorge ;Kapur, Sandip ;Irish, William ;McMichael, John ;Demetris, Anthony J. ;Starzl, Thomas E. ;Fung, John J. is a Medicine article available to read on EtoBox.

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The outcome of hepatitis C virus (HCV) infection on patient and graft survival after orthotopic liver transplantation (OLT) has been controversial. An earlier experience with a higher dose of tacrolimus (H0.1 mg/kg/d intravenously and H0.2 mg/ kg/d orally) was associated with a worse clinical outcome in patients infected with HCV. The clinical outcome of 183 liver transplant recipients with end-stage liver disease (ESLD) secondary to HCV infection (HCV group) was compared with a contemporary cohort of 556 patients with HCV infection who underwent transplantation for nonviral, nonmalignant ESLD (control group). All patients were prospectively screened for anti-HCV antibodies and HCV RNA by reverse-transcriptase polymerase chain reaction. All OLT patients were receiving low-dose tacrolimus immunosuppression. Cumulative patient survival rates for the HCV group were 80% after 1 year and 75% after 3 years compared with rates of 84% and 78%, respectively, in the control group (P ‫؍‬ .452). Primary graft survival rates at the same time intervals for the HCV group and the control group were 72% and 77.5% at 1 year and 67% and 72% at 3 years, respectively (P ‫؍‬ .144). The incidence of re-t

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Author

Casavilla, F. Adrian ;Rakela, Jorge ;Kapur, Sandip ;Irish, William ;McMichael, John ;Demetris, Anthony J. ;Starzl, Thomas E. ;Fung, John J.

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1074-3022)

Published

1998

Language

EN

Field

Medicine (Health Sciences)