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TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse by Marieli Gonzalez-Cotto; Liang Guo; Megan Karwan; Shurjo K. Sen; Jennifer Barb; Carlos J. Collado; Fathi Elloumi; Erika M. Palmieri; Kimberly Boelte; Frank D. Kolodgie; Aloke V. Finn; Leslie G. Biesecker; Daniel W. McVicar is a Immunology and Microbiology article available to read on EtoBox.
What is TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse about?
The Triggering Receptor Expressed on Myeloid cells-like 4 (TREML4) is a member of the TREM receptor family, known modulators of inflammatory responses. We have previously found that __TREML4__ expression positively correlates with human coronary arterial calcification (CAC). However, the role of __TREML4__ in the pathogenesis of cardiovascular disease remains incompletely defined. Since macrophages play a key role in inflammatory conditions, we investigated if activated macrophages selectively expressed __TREML4__ and found that carriage of either one of the eQTL SNP’s previously associated with increased __TREML4__ expression conferred higher expression in human inflammatory macrophages (M1) compared to alternatively activated macrophages (M2). Furthermore, we found that __TREML4__ expression in human M1 dysregulated several inflammatory pathways related to leukocyte activation, apoptosis and extracellular matrix degradation. Similarly, murine M1 expressed substantial levels of __Treml4__, as did oxLDL treated macrophages. Transcriptome analysis confirmed that murine __Treml4__ controls the expression of genes related to inflammation and lipid regulation pathways, suggesting a pos
Who reads TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Marieli Gonzalez-Cotto; Liang Guo; Megan Karwan; Shurjo K. Sen; Jennifer Barb; Carlos J. Collado; Fathi Elloumi; Erika M. Palmieri; Kimberly Boelte; Frank D. Kolodgie; Aloke V. Finn; Leslie G. Biesecker; Daniel W. McVicar
- Publisher
- Frontiers Media SA
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)