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Re-surgery and Chest Wall Re-irradiation for Recurrent Breast Cancer - a Second Curative Approach by Arndt-Christian Müller; Franziska Eckert; Vanessa Heinrich; Michael Bamberg; Sara Brucker; Thomas Hehr is a Medicine article available to read on EtoBox.

What is Re-surgery and Chest Wall Re-irradiation for Recurrent Breast Cancer - a Second Curative Approach about?

## Background Repeat radiation is a rarely used treatment strategy that must be performed with caution. The efficacy and toxicity of a second curative radiotherapy series was investigated in cases of recurrent breast cancer. ## Methods Forty-two patients treated from 1993 to 2003 with resection (n = 30) and postoperative re-irradiation or definitive re-irradiation (n = 12) for recurrent breast cancer were enrolled in the study. Concurrent hyperthermia was performed in 29 patients. The median age was 57 years. The median pre-radiation exposure was 54Gy. Re-irradiation was conventionally fractionated to a median total dose of 60Gy. ## Results After a median follow-up of 41 months (range 3-92 months) higher graded late toxicity > G3 according to CTC 3.0 and LENT-SOMA was not observed. The estimated 5-year local control rate reached 62%. The estimated 5-year overall survival rate was 59%. Significantly inferior survival was associated with recurrence within two years (40 vs. 71%, p < ([0-9]).01) and presence of macroscopic tumour load (24 vs. 75%, p = 0.03). ## Conclusions Repeat radiotherapy for recurrent breast cancer with total radiation doses of 60 Gy and the addition of hypertherm

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Author

Arndt-Christian Müller; Franziska Eckert; Vanessa Heinrich; Michael Bamberg; Sara Brucker; Thomas Hehr

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)

Published

2011

Language

EN

Field

Medicine (Health Sciences)