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Plasmacytoid Dendritic Cells in Inflamed Muscle of Patients with Juvenile Dermatomyositis by Consuelo M. López de Padilla; Abbe N. Vallejo; Kelly T. McNallan; Richard Vehe; Stephen A. Smith; Allan B. Dietz; Stanimir Vuk‐Pavlovic; Ann M. Reed is a Medicine article available to read on EtoBox.
What is Plasmacytoid Dendritic Cells in Inflamed Muscle of Patients with Juvenile Dermatomyositis about?
## Abstract ## Objective To examine whether dendritic cells (DCs) are constituents of muscle inflammation in juvenile dermatomyositis (DM). ## Methods The types, numbers, and activation state of DC subsets in inflamed muscle tissue from patients with juvenile DM and in noninflamed muscle tissue from control subjects were examined by multicolor immunofluorescence. Chemokine expression of the muscle‐infiltrating cells was examined by laser capture microdissection and quantitative polymerase chain reaction. ## Results Plasmacytoid DCs were the predominant component of the inflamed muscle tissue from patients with juvenile DM. These cells were identified by coexpression of CD4 and CD123, but not CD11c, and also expressed CD83, indicating maturity of the cells. In contrast, in noninflamed muscle, plasmacytoid DCs were scarce and did not express CD83. Mononuclear cells surrounding the blood vessels of inflamed muscle contained abundant transcripts of CCL19 and CCL21, but very little CCL18 transcripts. In contrast, cells from noninflamed muscle contained negligible amounts of CCL19 and CCL21, but had high amounts of CCL18. Both the inflamed and noninflamed muscle tissue had equivalent lev
Who reads Plasmacytoid Dendritic Cells in Inflamed Muscle of Patients with Juvenile Dermatomyositis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Consuelo M. López de Padilla; Abbe N. Vallejo; Kelly T. McNallan; Richard Vehe; Stephen A. Smith; Allan B. Dietz; Stanimir Vuk‐Pavlovic; Ann M. Reed
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)