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Transcription induction of c-Ki-ras with the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal and transformed liver cells by Sai On Chan; Susanna Siu Chun Wong; Desmond Chak Yew Yeung is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Results from nuclear run-off assays show that exposure of hepatocytes and Reuber H35B hepatoma cells to the tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), leads to enhanced transcription of c-Ki-ras gene. This increase in transcription in turn results in an accumulation of the functionally active c-Ki-ras message. The half life of c-Ki-ras message in both normal and transformed livers cells is not altered by TPA and is determined to be 3.5 hr. The induction of c-Ki-ras message is accompanied by an increase in the level of c-Ki-ras protein.

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Author

Sai On Chan; Susanna Siu Chun Wong; Desmond Chak Yew Yeung

Publisher

Springer; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC (ISSN 0300-8177)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)