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Control of reactive site in palladium-catalyzed Grignard cross-coupling of arenes containing both bromide and triflate by Takashi Kamikawa; Tamio Hayashi is a Chemistry article available to read on EtoBox.
What is Control of reactive site in palladium-catalyzed Grignard cross-coupling of arenes containing both bromide and triflate about?
Reaction of 4-bromophenyl triflate (1) with phenylmagnesium bromide in the presence of 5 mol % of PdC12(dppp) gave 97% yield of 4-bromobiphenyl (2a), which was formed by selective replacement of triflate in 1 by phenyl. On the other hand, bromide in 1 was substituted with the phenyl Grignard reagent selectively by use of PdCl2(meo-mop)2 to give 4biphenyl triflate (3a) in high yield. The selective substitution was demonstrated to take place at the oxidative addition step to a palladium(0) species in a stoichiometric reaction of 1 with palladium(0) phosphine complexes.
Who reads Control of reactive site in palladium-catalyzed Grignard cross-coupling of arenes containing both bromide and triflate?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Takashi Kamikawa; Tamio Hayashi
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 1997
- Language
- EN
- Field
- Chemistry (Physical Sciences)