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Oxidative stress-related circulating miRNA-27a is a potential biomarker for diagnosis and prognosis in patients with sepsis by Yingwei Ou; Rongcheng An; Haochu Wang; Lue Chen; Yong Shen; Wenwei Cai; Wei Zhu is a Immunology and Microbiology article available to read on EtoBox.

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## Abstract ## Background Oxidative stress plays a critical role on the processes of sepsis, and several microRNAs have been identified that may regulate the occurrence of oxidative stress. However, the relation between oxidative stress-related microRNA 27a (miR-27a) and sepsis is unknown. The present study aimed to determine the value of circulating miR-27a for the diagnosis and prognosis of sepsis. ## Methods This retrospective study included 23 patients with sepsis and 25 without sepsis treated at the emergency intensive care unit (EICU) or our institution between January 2019 and January 2020. Levels of circulating miR-27a and levels of oxidative stress-related indicators were measured and compared between sepsis and non-sepsis patients. Receiver operating characteristic (ROC) curve analysis was used to determine diagnostic efficiency of miR-27a. ## Results Circulating miR-27a levels in sepsis patients were higher than those in non-sepsis patients (p < 0.05), and levels were significantly higher in patients that died than those that lived (p < 0.05). In patients with sepsis, circulating miR-27a level was positively correlated with serum malondialdehyde (MDA) level (rs = 0.529,

Who reads Oxidative stress-related circulating miRNA-27a is a potential biomarker for diagnosis and prognosis in patients with sepsis?

Author

Yingwei Ou; Rongcheng An; Haochu Wang; Lue Chen; Yong Shen; Wenwei Cai; Wei Zhu

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Immunology and Microbiology (Life Sciences)