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Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease by Junhua Xie; Nina Gorlé; Charysse Vandendriessche; Griet Van Imschoot; Elien Van Wonterghem; Caroline Van Cauwenberghe; Eef Parthoens; Evelien Van Hamme; Saskia Lippens; Lien Van Hoecke; Roosmarijn E. Vandenbroucke is a Medicine article available to read on EtoBox.
What is Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease about?
## Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflammation plays a key role in both the initiation and progression of AD. Moreover, also the presence of peripheral inflammation has been extensively documented. However, it is still ambiguous whether this observed inflammation is cause or consequence of AD pathogenesis. Recently, this has been studied using amyloid precursor protein (APP) overexpression mouse models of AD. However, the findings might be confounded by APP-overexpression artifacts. Here, we investigated the effect of low-grade peripheral inflammation in the APP knock-in (App^NL-G-F^) mouse model. This revealed that low-grade peripheral inflammation affects (1) microglia characteristics, (2) blood-cerebrospinal fluid barrier integrity, (3) peripheral immune cell infiltration and (4) Aβ deposition in the brain. Next, we identified mechanisms that might cause this effect on AD pathology, more precisely Aβ efflux, persistent microglial activation and insufficient Aβ clearance, neuronal dysfunction and promoti
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- Author
- Junhua Xie; Nina Gorlé; Charysse Vandendriessche; Griet Van Imschoot; Elien Van Wonterghem; Caroline Van Cauwenberghe; Eef Parthoens; Evelien Van Hamme; Saskia Lippens; Lien Van Hoecke; Roosmarijn E. Vandenbroucke
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)