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Computation and analysis of time-dependent sensitivities in Generalized Mass Action systems by John H. Schwacke; Eberhard O. Voit is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Understanding biochemical system dynamics is becoming increasingly important for insights into the functioning of organisms and for biotechnological manipulations, and additional techniques and methods are needed to facilitate investigations of dynamical properties of systems. Extensions to the method of Ingalls and Sauro, addressing time-dependent sensitivity analysis, provide a new tool for executing such investigations. We present here the results of sample analyses using time-dependent sensitivities for three model systems taken from the literature, namely an anaerobic fermentation pathway in yeast, a negative feedback oscillator modeling cell-cycle phenomena, and the Mitogen Activated Protein (MAP) kinase cascade. The power of time-dependent sensitivities is particularly evident in the case of the MAPK cascade. In this example it is possible to identify the emergence of a concentration of MAPKK that provides the best response with respect to rapid and efficient activation of the cascade, while overand under-expression of MAPKK relative to this concentration have qualitatively different effects on the transient response of the cascade. Also of interest is the quite general obse

Who reads Computation and analysis of time-dependent sensitivities in Generalized Mass Action systems?

Author

John H. Schwacke; Eberhard O. Voit

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)