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Prothrombin A19911G and G20210A polymorphisms' role in thrombosis by Elena Pérez-Ceballos; Javier Corral; Ignacio Alberca; Amparo Vayá; Pilar Llamas; Ramón Montes; Rocio González-Conejero; Vicente Vicente is a Medicine article available to read on EtoBox.

**Summary.** The prothrombin G20210A polymorphism, which correlates with the plasmatic prothombin levels, is the second genetic risk factor for deep venous thrombosis (DVT), although its prothrombotic role is mild. Recently, the prothrombin A19911G polymorphism, also associated with slight variations of the prothrombin level, has been suggested to modulate the thrombotic risk of the G20210A polymorphism in a preliminary study including few patients and controls. Our study evaluated the effect of the A19911G polymorphism in the arterial and venous thrombotic risk of the prothrombin 20210G/A genotype, analysing 204 consecutive DVT patients and 204 matched controls. Moreover, we analysed 213 carriers of the 20210G/A genotype (152 with DVT, 26 with arterial thrombosis and 35 healthy subjects) and 10 homozygous 20210 A/A carriers. We developed a simple method to simultaneously determine the genotype of both polymorphisms. In accordance with our case/control study, the A19911G polymorphism did not play a significant role in the development of DVT. Analysis of 120 20210 A alleles demonstrated a complete linkage disequilibrium with the 19911 A allele. These polymorphisms (alone or combined

Author

Elena Pérez-Ceballos; Javier Corral; Ignacio Alberca; Amparo Vayá; Pilar Llamas; Ramón Montes; Rocio González-Conejero; Vicente Vicente

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2002

Language

EN

Field

Medicine (Health Sciences)