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Structure–permeability Relationship Analysis of the Permeation Barrier Properties of the Stratum Corneum and Viable Epidermis/dermis of Rat Skin by Koji Yamaguchi; Tetsuya Mitsui; Yoshinori Aso; Kenji Sugibayashi is a Chemistry article available to read on EtoBox.

What is Structure–permeability Relationship Analysis of the Permeation Barrier Properties of the Stratum Corneum and Viable Epidermis/dermis of Rat Skin about?

The purpose of this study was to evaluate structure-permeability relationships for chemicals through stratum corneum (SC) and viable epidermis/dermis (VED). In vitro skin permeation of ten compounds through excised rat skin was analyzed based on a two-layer diffusion model and the diffusion coefficients in SC (D(SC)) and VED (D(VED)) were determined. The relationships between the permeation parameters and the physicochemical parameters (octanol-water partition coefficient (log K(o/w)), and hydrogen bond donor number (HBD)) of the compounds were analyzed. D(SC) increased as lipophilicity increased, whereas D(VED) decreased for log K(o/w) > 2. Increases in log K(o/w) caused a decrease in the permeability coefficient from SC through VED (P(VED/SC)) for log K(o/w) > 1. The simulation study suggests that the in vitro skin permeation of a highly lipophilic compound is strongly controlled by skin thickness due to low diffusivity in VED. The present study suggests that VED act as a considerable permeation barrier for highly lipophilic compounds due to low diffusivity.

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Author

Koji Yamaguchi; Tetsuya Mitsui; Yoshinori Aso; Kenji Sugibayashi

Publisher

John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)