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What is TRKB Signaling Underlies Ketamine Actions2021 about?

Lin et al. demonstrate that BDNF signaling through postsynaptic TrkB at CA3-CA1 synapses is crucial for the rapid antidepressant action of ketamine. The study shows that deletion of BDNF or TrkB in specific hippocampal regions blocks ketamine-induced synaptic potentiation, highlighting the importance of BDNF-TrkB signaling in mediating ketamine

Author

trentsunhk

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EN