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Can I read Oxandrolone Does Not Improve Outcome of Ventilator Dependent Surgical Patients on EtoBox?
Oxandrolone Does Not Improve Outcome of Ventilator Dependent Surgical Patients by Eileen M. Bulger; Gregory J. Jurkovich; Catherine L. Farver; Patricia Klotz; Ronald V. Maier is a Medicine article available to read on EtoBox.
What is Oxandrolone Does Not Improve Outcome of Ventilator Dependent Surgical Patients about?
Background: Multisystem injury and major surgical stress result in a hypermetabolic state with accelerated breakdown of protein stores. Loss of lean muscle mass impairs wound healing, increases infection rates, and weakens respiratory musculature. Oxandrolone is an anabolic steroid that attenuates loss of lean body mass and improves wound healing in burn patients. We hypothesized that oxandrolone would improve outcome for ventilator-dependent surgical patients. Methods: We conducted a randomized, double-blind, placebocontrolled trial of oxandrolone therapy for surgical/trauma patients requiring Ͼ7 days of ventilation. The primary end point was time on the ventilator. Results: Forty-one patients were enrolled between January 1, 2001, and June 15, 2003, 18 received oxandrolone (10 mg po BID) and 23 received a placebo. Groups were comparable for age, gender, injury severity score, and APACHE II score. The majority were trauma patients (83%), and 90% received enteral feeding. The oxandrolone group received higher caloric and protein intake before enrollment, but these differences were not significant. Contrary to our hypothesis, patients receiving oxandrolone spent significantly longer
Who reads Oxandrolone Does Not Improve Outcome of Ventilator Dependent Surgical Patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eileen M. Bulger; Gregory J. Jurkovich; Catherine L. Farver; Patricia Klotz; Ronald V. Maier
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)