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Clinical Trial of Bleaching Treatment With 10% All-Trans Retinol Gel by Kotaro Yoshimura; Akira Momosawa; Emiko Aiba; Katsujiro Sato; Daisuke Matsumoto; Yoko Mitoma; Kiyonori Harii; Takao Aoyama; Tatsuji Iga is a Medicine article available to read on EtoBox.

What is Clinical Trial of Bleaching Treatment With 10% All-Trans Retinol Gel about?

## Background: Although an aggressive use of tretinoin along with hydroquinone enables an efficient treatment of hyperpigmented skin lesions, irritant dermatitis remains to be solved. ## Objective: To evaluate the efficiency and adverse effects of 10% all-trans retinol (rol) gel for improvement of skin hyperpigmentation. ## Methods: Ten-percent rol gel was used instead of 0.1% tretinoin gel in our two-phased bleaching protocol (bleaching and healing phases); 5% hydroquinone and 7% lactic acid ointment were used along with rol gel in the bleaching phase (2 to 6 weeks). five-percent hydroquinone and 7% ascorbic acid ointment were used alone during the healing phase (4 to 6 weeks). twenty-one japanese patients with hyperpigmented lesions on the face were enrolled in this study, and 18 patients who were followed for more than 10 weeks were analyzed. ## Results: Improvement of pigmentation was seen in 16 of 18 patients after an average treatment period of 11.3 weeks, and in 6 patients, pigmentation was almost eliminated after treatment. erythema and scaling were seen, however, during the bleaching phase as well as the bleaching treatment with tretinoin gel. ## Conclusion: Rol can improv

Who reads Clinical Trial of Bleaching Treatment With 10% All-Trans Retinol Gel?

Author

Kotaro Yoshimura; Akira Momosawa; Emiko Aiba; Katsujiro Sato; Daisuke Matsumoto; Yoko Mitoma; Kiyonori Harii; Takao Aoyama; Tatsuji Iga

Publisher

John Wiley and Sons; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Wolters Kluwer Health; Ovid Technologies (Wolters Kluwer Health); Elsevier BV (ISSN 1076-0512)

Published

2003

Language

EN

Field

Medicine (Health Sciences)