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What is Allosteric Transitions in pLGIC Structure about?

1) The study examines the structural basis of allosteric transitions in DeCLIC, a multidomain pentameric ligand-gated ion channel from a bacterium. 2) X-ray crystallography revealed two conformational states - a closed state with calcium bound at the ligand binding domain interface, and an open state without calcium with a remodeled periplasmic domain. 3) Functional analysis found that currents only occurred when extracellular calcium was depleted, and the channel paralleled properties of another prokary

Author

Anisa Firdaus

Language

EN