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Maternal folic acid supplementation and more prominent birth weight gain in twin birth compared with singleton birth: a cross-sectional study in northwest China by Binyan Zhang; Suhang Shang; Shanshan Li; Baibing Mi; Minmin Li; Guoshuai Shi; Mao Ma; Qian Wang; Hong Yan; Shaonong Dang is a Medicine article available to read on EtoBox.
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## Abstract ## Objective: To investigate the association of folic acid (FA) supplementation with birth weight, the risk of small for gestational age (SGA) and low birth weight (LBW) in singleton and twin pregnancy. ## Design: A population-based cross-sectional survey. ## Setting: Twenty counties and ten districts in Shaanxi Province of northwestern China, 2013. ## Participants: 28 174 pregnant women with their infants, covering 27 818 single live births and 356 twin live births. ## Results: The prevalence of FA supplementation in singletons and twins was 63·9 and 66·3 %. The mean birth weight was 3267 (sd 459·1) g, 2525 (sd 534·0) g and 2494 (sd 539·5) g; the prevalence of SGA was 14·3, 51·4 and 53·4 %; the prevalence of LBW was 3·4, 42·4 and 46·6 % among singleton, twin A and twin B, respectively. Compared with non-users, women with FA supplementation were (β 17·3, 95 % CI 6·1, 28·4; β 166·3, 95 % CI 69·1, 263·5) associated with increased birth weight, lower risk of SGA (OR 0·85, 95 % CI 0·80, 0·92; OR 0·45, 95 % CI 0·30, 0·68) and LBW (OR 0·82, 95 % CI 0·71, 0·95; OR 0·50, 95 % CI 0·33, 0·75) in singletons and twins, and more prominent effects in twins. Moreover, there were signi
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- Author
- Binyan Zhang; Suhang Shang; Shanshan Li; Baibing Mi; Minmin Li; Guoshuai Shi; Mao Ma; Qian Wang; Hong Yan; Shaonong Dang
- Publisher
- Cambridge University Press (CUP)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)