Can I read Affinity-based Electrochemical Sensors for Biomolecular Detection in Whole Blood on EtoBox?

Affinity-based Electrochemical Sensors for Biomolecular Detection in Whole Blood by Elizabeth C. Wilkirson; Kavya L. Singampalli; Jiran Li; Desh Deepak Dixit; Xue Jiang; Diego H. Gonzalez; Peter B. Lillehoj is a Chemistry article available to read on EtoBox.

What is Affinity-based Electrochemical Sensors for Biomolecular Detection in Whole Blood about?

The detection and/or quantification of biomarkers in blood is important for the early detection, diagnosis, and treatment of a variety of diseases and medical conditions. Among the different types of sensors for detecting molecular biomarkers, such as proteins, nucleic acids, and small-molecule drugs, affinity-based electrochemical sensors offer the advantages of high analytical sensitivity and specificity, fast detection times, simple operation, and portability. However, biomolecular detection in whole blood is challenging due to its highly complex matrix, necessitating sample purification (i.e., centrifugation), which involves the use of bulky, expensive equipment and tedious sample-handling procedures. To address these challenges, various strategies have been employed, such as purifying the blood sample directly on the sensor, employing micro-/nanoparticles to enhance the detection signal, and coating the electrode surface with blocking agents to reduce nonspecific binding, to improve the analytical performance of affinity-based electrochemical sensors without requiring sample pre-processing steps or laboratory equipment. In this article, we present an overview of affinity-based

Who reads Affinity-based Electrochemical Sensors for Biomolecular Detection in Whole Blood?

Author

Elizabeth C. Wilkirson; Kavya L. Singampalli; Jiran Li; Desh Deepak Dixit; Xue Jiang; Diego H. Gonzalez; Peter B. Lillehoj

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)