About this Medicine article
Impact of Acquired Broad-Spectrum β-Lactamases on Susceptibility to Cefiderocol and Newly Developed β-Lactam/β-Lactamase Inhibitor Combinations in Escherichia coli and Pseudomonas aeruginosa by Laurent Poirel; Jose-Manuel Ortiz de la Rosa; Mustafa Sadek; Patrice Nordmann is a Medicine article available to read on EtoBox.
The ability of broad-spectrum β-lactamases to reduce the susceptibility to ceftazidime-avibactam (CZA), ceftolozane-tazobactam (C/T), imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam (AZA), and cefiderocol (FDC) was evaluated both in Pseudomonas aeruginosa and in Escherichia coli using isogenic backgrounds. Although metallo-β-lactamases conferred resistance in most cases, except for AZA, several clavulanic-acid-inhibited extended-spectrum β-lactamases (PER, BEL, SHV) had a significant impact on the susceptibility to CZA, C/T, and FDC.
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- Author
- Laurent Poirel; Jose-Manuel Ortiz de la Rosa; Mustafa Sadek; Patrice Nordmann
- Publisher
- American Society for Microbiology
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)