Can I read Influence of Poly(3‐hydroxybutyrate‐ Co ‐4‐Hydroxybutyrate‐ Co ‐3‐Hydroxyhexanoate) on Growth and Osteogenic Differentiation of Human Bone Marrow‐derived Mesenchymal Stem Cells on EtoBox?

Influence of Poly(3‐hydroxybutyrate‐ Co ‐4‐Hydroxybutyrate‐ Co ‐3‐Hydroxyhexanoate) on Growth and Osteogenic Differentiation of Human Bone Marrow‐derived Mesenchymal Stem Cells by Xing Wei; Ya‐Jun Hu; Wen‐Peng Xie; Ruo‐Ling Lin; Guo‐Qiang Chen is a Engineering article available to read on EtoBox.

What is Influence of Poly(3‐hydroxybutyrate‐ Co ‐4‐Hydroxybutyrate‐ Co ‐3‐Hydroxyhexanoate) on Growth and Osteogenic Differentiation of Human Bone Marrow‐derived Mesenchymal Stem Cells about?

## Abstract As a new member of polyhydroxyalkanoate (PHA) family, the novel polyester poly(3‐hydroxybutyrate‐__co__‐4‐hydroxybutyrate‐__co__‐3‐hydroxyhexanoate) (P(3HB‐4HB‐3HHx)) was produced by recombinant __Aeromonas hydrophila__ 4AK4 and used for the first time to test its biocompatibility. It was shown that P(3HB‐4HB‐3HHx) had higher hydrophobicity, surface energy, and rougher surface than the well‐studied polymers poly(L‐lactic acid) (PLA) and poly(3‐hydroxybutyrate‐__co__‐3‐hydroxyhexanoate) (PHBHHx). Human mesenchymal stem cells (MSCs) attached better on P(3HB‐4HB‐3HHx) film than on tissue culture plates (TCPs), PLA film, and PHBHHx film. MSC proliferation on P(3HB‐4HB‐3HHx) film was 126% higher than that on TCPs, 84% higher than that on PHBHHx film, and 312% higher than that on PLA film (__p__ < 0.01). P(3HB‐4HB‐3HHx) also supported osteogenic differentiation of MSCs. Previous studies found that all PHA materials tested were either less than or equal to TCPs for supporting cell growth. Among all PHA materials tested, P(3HB‐4HB‐3HHx) was the only PHA material to significantly promote cell proliferation compared with TCPs. P(3HB‐4HB‐3HHx) could be exploited for applications i

Who reads Influence of Poly(3‐hydroxybutyrate‐ Co ‐4‐Hydroxybutyrate‐ Co ‐3‐Hydroxyhexanoate) on Growth and Osteogenic Differentiation of Human Bone Marrow‐derived Mesenchymal Stem Cells?

Author

Xing Wei; Ya‐Jun Hu; Wen‐Peng Xie; Ruo‐Ling Lin; Guo‐Qiang Chen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2008

Language

EN

Field

Engineering (Physical Sciences)