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Hyaluronic Acid Grafting Mitigates Calcification of Glutaraldehyde-fixed Bovine Pericardium by Rachit Ohri; Sei K. Hahn; Allan S. Hoffman; Patrick S. Stayton; Cecilia M. Giachelli is a Medicine article available to read on EtoBox.

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## Abstract Pathologic calcification is the leading cause of the clinical failure of glutaraldehyde‐fixed bovine pericardium used in bioprosthetic valves. A novel surface modification of glutaraldehyde fixed bovine pericardium was carried out with high molecular weight hyaluronic acid (HA). HA was chemically modified with adipic dihydrazide (ADH) to introduce hydrazide functional groups onto the HA backbone. Glutaraldehyde‐fixed bovine pericardium (GFBP) was modified by grafting this HA to the free aldehyde groups on the tissue via the hydrazide groups. Following a 2‐week subcutaneous implantation in osteopontin (OPN)‐null mice, the calcification of HA‐modified bovine pericardium was drastically reduced (by 84.5%) compared to positive controls (tissue without HA‐modification) (__p__ = 0.005). The calcification‐mitigating effect of HA surface modification was also confirmed by microscopic analysis of explanted tissue stained with Alizarin Red S for calcium. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 328–334, 2004

Who reads Hyaluronic Acid Grafting Mitigates Calcification of Glutaraldehyde-fixed Bovine Pericardium?

Author

Rachit Ohri; Sei K. Hahn; Allan S. Hoffman; Patrick S. Stayton; Cecilia M. Giachelli

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2004

Language

EN

Field

Medicine (Health Sciences)