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Mitochondrial Pathway Is Involved in Hydrogen‐peroxide‐induced Apoptotic Cell Death of Oligodendrocytes by Thomas Mronga; Thomas Stahnke; Olaf Goldbaum; Christiane Richter‐Landsberg is a Neuroscience article available to read on EtoBox.

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## Abstract Oligodendrocytes, the myelin‐forming cells of the CNS, are specifically sensitive to oxidative stress and respond by the onset of programmed cell death (PCD). To further unravel the molecular events underlying their enhanced susceptibility, we have investigated whether mitochondrial damage occurs during oxidative stress‐induced PCD in cultured rat brain oligodendrocytes. Mitochondria are considered as a central control point of apoptosis, and mitochondrial dysfunction has been linked to neurodegenerative disease. Upon a number of stimuli through the release of cytochrome c, they coordinate caspase activation, causing morphological and biochemical changes associated with PCD. Oxidative stress was exerted by the application of hydrogen peroxide. The data show that hydrogen peroxide‐induced apoptosis in oligodendrocytes involves mitochondrial damage and cytochrome c release and is accompanied by the activation of the death‐related caspases 3 and 9. Concomitantly, the activation and nuclear translocation of extracellular signal regulated kinases ERK1,2 are observed, which have been implicated to participate in the regulation of cell death and survival. DNA fragmentation cou

Who reads Mitochondrial Pathway Is Involved in Hydrogen‐peroxide‐induced Apoptotic Cell Death of Oligodendrocytes?

Author

Thomas Mronga; Thomas Stahnke; Olaf Goldbaum; Christiane Richter‐Landsberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)

Published

2004

Language

EN

Field

Neuroscience (Life Sciences)