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Can I read 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase on EtoBox?
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase by Paul Bamborough; John A. Christopher; Geoffrey J. Cutler; Marion C. Dickson; Geoffrey W. Mellor; James V. Morey; Champa B. Patel; Lisa M. Shewchuk is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase about?
The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-e kinase is described. Compound 12e was identified with an IKK-e enzyme potency of pIC 50 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.
Who reads 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Paul Bamborough; John A. Christopher; Geoffrey J. Cutler; Marion C. Dickson; Geoffrey W. Mellor; James V. Morey; Champa B. Patel; Lisa M. Shewchuk
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)