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C10orf99 Contributes to the Development of Psoriasis by Promoting the Proliferation of Keratinocytes by Caifeng Chen; Na Wu; Qiqi Duan; Huizi Yang; Xin Wang; Peiwen Yang; Mengdi Zhang; Jiankang Liu; Zhi Liu; Yongping Shao; Yan Zheng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is C10orf99 Contributes to the Development of Psoriasis by Promoting the Proliferation of Keratinocytes about?
## Abstract Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles of C10orf99 in epidermal proliferation under inflammatory condition. We showed that C10orf99 protein was significantly up-regulated in psoriatic skin samples from patients and the ortholog gene expression levels were up-regulated in imiquimod (IMQ)-induced psoriasis-like skin lesions in mice. Using M5-stimulated HaCaT cell line model of inflammation and a combinational approach of knockdown and overexpression of C10orf99, we demonstrated that C10orf99 could promote keratinocyte proliferation by facilitating the G1/S transition, and the pro-proliferation effect of C10orf99 was associated with the activation of the ERK1/2 and NF-κB but not the AKT pathways. Local depletion of C10orf99 by lentiviral vectors expressing C10orf99 shRNA effectively ameliorated IMQ-induced dermatitis. Taken together, these results indicate that C10orf99 plays a contributive role in
Who reads C10orf99 Contributes to the Development of Psoriasis by Promoting the Proliferation of Keratinocytes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Caifeng Chen; Na Wu; Qiqi Duan; Huizi Yang; Xin Wang; Peiwen Yang; Mengdi Zhang; Jiankang Liu; Zhi Liu; Yongping Shao; Yan Zheng
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)