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Hemodynamic Response and Clinical Outcome Following Intravenous Milrinone Plus Norepinephrine–based Hyperdynamic Hypertensive Therapy in Patients Suffering Secondary Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage by Hans-Jakob Steiger; Rolf Ensner; Lukas Andereggen; Luca Remonda; Jatta Berberat; Serge Marbacher is a Medicine article available to read on EtoBox.

What is Hemodynamic Response and Clinical Outcome Following Intravenous Milrinone Plus Norepinephrine–based Hyperdynamic Hypertensive Therapy in Patients Suffering Secondary Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage about?

## Abstract ## Purpose Intravenous and intra-arterial milrinone as a rescue measure for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) has been adopted by several groups, but so far, evidence for the clinical benefit is unclear and effect on brain perfusion is unknown. The aim of the actual analysis was to define cerebral hemodynamic effects and outcome of intravenous milrinone plus norepinephrine supplemented by intra-arterial nimodipine as a rescue strategy for DCI following aneurysmal SAH. ## Methods Of 176 patients with aneurysmal SAH treated at our neurosurgical department between April 2016 and March 2021, 98 suffered from DCI and were submitted to rescue therapy. For the current analysis, characteristics of these patients and clinical response to rescue therapy were correlated with hemodynamic parameters, as assessed by CT angiography (CTA) and perfusion CT. Time to peak (TTP) delay in the ischemic focus and the volume with a TTP delay of more than 4 s (T4 volume) were used as hemodynamic parameters. ## Results The median delay to neurological deterioration following SAH was 5 days. Perfusion CT at that time showed median T4 volumes of 40 cc and mean foc

Who reads Hemodynamic Response and Clinical Outcome Following Intravenous Milrinone Plus Norepinephrine–based Hyperdynamic Hypertensive Therapy in Patients Suffering Secondary Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage?

Author

Hans-Jakob Steiger; Rolf Ensner; Lukas Andereggen; Luca Remonda; Jatta Berberat; Serge Marbacher

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)