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This document describes optimization of acetonitrile co-solvent and copper stoichiometry for click chemistry labeling of nucleic acids. The authors found that very low concentrations of acetonitrile as a co-solvent can serve as a ligand to stabilize copper(I) and allow for click chemistry reactions with nucleic acids in aqueous buffer without an additional ligand. Testing different ratios of copper(I) and acetonitrile, they determined that 10 equivalents of copper(I) and 0.6% acetonitrile allowed for maxima

Author

Gizwa Aiichaicchapratiwie

Language

EN