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Prevalence of Abnormal Spirometry in Individuals with a Smoking History and No Known Obstructive Lung Disease by Thuonghien V. Tran; Gregory L. Kinney; Alejandro Comellas; Karin F. Hoth; Arianne K. Baldomero; A. James Mamary; Jeffrey L. Curtis; Nicola Hanania; Richard Casaburi; Kendra A. Young; Victor Kim; Barry Make; Emily S. Wan; Alejandro A. Diaz; John Hokanson; James D. Crapo; Edwin K. Silverman; Surya P. Bhatt; Elizabeth Regan; Spyridon Fortis; James D. Crapo; Edwin K. Silverman; Barry J. Make; Elizabeth A. Regan; Terri H. Beaty; Peter J. Castaldi; Michael H. Cho; Dawn L. DeMeo; Adel El Boueiz; Marilyn G. Foreman; Auyon Ghosh; Lystra P. Hayden; Craig P. Hersh; Jacqueline Hetmanski; Brian D. Hobbs; John E. Hokanson; Wonji Kim; Nan Laird; Christoph Lange; Sharon M. Lutz; Merry-Lynn McDonald; Dmitry Prokopenko; Matthew Moll; Jarrett Morrow; Dandi Qiao; Elizabeth A. Regan; Aabida Saferali; Phuwanat Sakornsakolpat; Edwin K. Silverman; Emily S. Wan; Jeong Yun; Juan Pablo Centeno; Jean-Paul Charbonnier; Harvey O. Coxson; Craig J. Galban; MeiLan K. Han; Eric A. Hoffman; Stephen Humphries; Francine L. Jacobson; Philip F. Judy; Ella A. Kazerooni; Alex Kluiber; David A. Lynch; Pietro Nardelli; John D. Newell; Aleena Notary; Andrea Oh; Elizabeth A. Regan; James C. Ross; Raul San Jose Estepar; Joyce Schroeder; Jered Sieren; Berend C. Stoel; Juerg Tschirren; Edwin Van Beek; Bram van Ginneken; Eva van Rikxoort; Gonzalo Vegas Sanchez Ferrero; Lucas Veitel; George R. Washko; Carla G. Wilson; Robert Jensen; Douglas Everett; Jim Crooks; Katherine Pratte; Matt Strand; Carla G. Wilson; John E. Hokanson; Erin Austin; Gregory Kinney; Sharon M. Lutz; Kendra A. Young; Surya P. Bhatt; Jessica Bon; Alejandro A. Diaz; MeiLan K. Han; Barry Make; Susan Murray; Elizabeth Regan; Xavier Soler; Carla G. Wilson; Russell P. Bowler; Katerina Kechris; Farnoush BanaeiKashani; Jeffrey L. Curtis; Perry G. Pernicano; Nicola Hanania; Mustafa Atik; Aladin Boriek; Kalpatha Guntupalli; Elizabeth Guy; Amit Parulekar; Dawn L. DeMeo; Craig Hersh; Francine L. Jacobson; George Washko; R. Graham Barr; John Austin; Belinda D'Souza; Byron Thomashow; Neil MacIntyre; H. Page McAdams; Lacey Washington; Charlene McEvoy; Joseph Tashjian; Robert Wise; Robert Brown; Nadia N. Hansel; Karen Horton; Allison Lambert; Nirupama Putcha; Richard Casaburi; Alessandra Adami; Matthew Budoff; Hans Fischer; Janos Porszasz; Harry Rossiter; William Stringer; Amir Sharafkhaneh; Charlie Lan; Christine Wendt; Brian Bell; Ken M. Kunisaki; Eric L. Flenaugh; Hirut Gebrekristos; Mario Ponce; Silanath Terpenning; Gloria Westney; Russell Bowler; David A. Lynch; Richard Rosiello; David Pace; Gerard Criner; David Ciccolella; Francis Cordova; Chandra Dass; Gilbert D'Alonzo; Parag Desai; Michael Jacobs; Steven Kelsen; Victor Kim; A. James Mamary; Nathaniel Marchetti; Aditi Satti; Kartik Shenoy; Robert M. Steiner; Alex Swift; Irene Swift; Maria Elena Vega-Sanchez; Mark Dransfield; William Bailey; Surya P. Bhatt; Anand Iyer; Hrudaya Nath; J. Michael Wells; Douglas Conrad; Xavier Soler; Andrew Yen; Alejandro P. Comellas; Karin F. Hoth; John Newell; Brad Thompson; MeiLan K. Han; Ella Kazerooni; Wassim Labaki; Craig Galban; Dharshan Vummidi; Joanne Billings; Abbie Begnaud; Tadashi Allen; Frank Sciurba; Jessica Bon; Divay Chandra; Joel Weissfeld; Antonio Anzueto; Sandra Adams; Diego Maselli-Caceres; Mario E. Ruiz; Harjinder Singh is a Medicine article available to read on EtoBox.
What is Prevalence of Abnormal Spirometry in Individuals with a Smoking History and No Known Obstructive Lung Disease about?
Introduction Recent evidence suggests a high prevalence of undiagnosed chronic obstructive pulmonary disease (COPD). These individuals are at risk of exacerbations and delayed treatment. We analyzed an at-risk population for the prevalence of abnormal spirometry to provide clarity into who should undergo early spirometry. Methods We analyzed data from the COPDGene study. Participants with ≥10 pack-years of smoking were included. Individuals with self-reported or physician-diagnosed COPD, asthma, chronic bronchitis, emphysema and/or were on inhalers were excluded. Parsimonious multivariable logistic regression models identified factors associated with abnormal spirometry, defined as either airflow obstruction (AFO) or preserved ratio impaired spirometry. Variables were selected for the final model using a stepwise backward variable elimination process which minimized Akaike information criterion (AIC). Similarly, during the 5-year follow-up period, we assessed factors associated with incident diagnosis of COPD. Results Of 5055 individuals, 1064 (21%) had undiagnosed AFO. Age, pack-years, current smoking and a history of acute bronchitis were associated with AFO while body mass index
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- Author
- Thuonghien V. Tran; Gregory L. Kinney; Alejandro Comellas; Karin F. Hoth; Arianne K. Baldomero; A. James Mamary; Jeffrey L. Curtis; Nicola Hanania; Richard Casaburi; Kendra A. Young; Victor Kim; Barry Make; Emily S. Wan; Alejandro A. Diaz; John Hokanson; James D. Crapo; Edwin K. Silverman; Surya P. Bhatt; Elizabeth Regan; Spyridon Fortis; James D. Crapo; Edwin K. Silverman; Barry J. Make; Elizabeth A. Regan; Terri H. Beaty; Peter J. Castaldi; Michael H. Cho; Dawn L. DeMeo; Adel El Boueiz; Marilyn G. Foreman; Auyon Ghosh; Lystra P. Hayden; Craig P. Hersh; Jacqueline Hetmanski; Brian D. Hobbs; John E. Hokanson; Wonji Kim; Nan Laird; Christoph Lange; Sharon M. Lutz; Merry-Lynn McDonald; Dmitry Prokopenko; Matthew Moll; Jarrett Morrow; Dandi Qiao; Elizabeth A. Regan; Aabida Saferali; Phuwanat Sakornsakolpat; Edwin K. Silverman; Emily S. Wan; Jeong Yun; Juan Pablo Centeno; Jean-Paul Charbonnier; Harvey O. Coxson; Craig J. Galban; MeiLan K. Han; Eric A. Hoffman; Stephen Humphries; Francine L. Jacobson; Philip F. Judy; Ella A. Kazerooni; Alex Kluiber; David A. Lynch; Pietro Nardelli; John D. Newell; Aleena Notary; Andrea Oh; Elizabeth A. Regan; James C. Ross; Raul San Jose Estepar; Joyce Schroeder; Jered Sieren; Berend C. Stoel; Juerg Tschirren; Edwin Van Beek; Bram van Ginneken; Eva van Rikxoort; Gonzalo Vegas Sanchez Ferrero; Lucas Veitel; George R. Washko; Carla G. Wilson; Robert Jensen; Douglas Everett; Jim Crooks; Katherine Pratte; Matt Strand; Carla G. Wilson; John E. Hokanson; Erin Austin; Gregory Kinney; Sharon M. Lutz; Kendra A. Young; Surya P. Bhatt; Jessica Bon; Alejandro A. Diaz; MeiLan K. Han; Barry Make; Susan Murray; Elizabeth Regan; Xavier Soler; Carla G. Wilson; Russell P. Bowler; Katerina Kechris; Farnoush BanaeiKashani; Jeffrey L. Curtis; Perry G. Pernicano; Nicola Hanania; Mustafa Atik; Aladin Boriek; Kalpatha Guntupalli; Elizabeth Guy; Amit Parulekar; Dawn L. DeMeo; Craig Hersh; Francine L. Jacobson; George Washko; R. Graham Barr; John Austin; Belinda D'Souza; Byron Thomashow; Neil MacIntyre; H. Page McAdams; Lacey Washington; Charlene McEvoy; Joseph Tashjian; Robert Wise; Robert Brown; Nadia N. Hansel; Karen Horton; Allison Lambert; Nirupama Putcha; Richard Casaburi; Alessandra Adami; Matthew Budoff; Hans Fischer; Janos Porszasz; Harry Rossiter; William Stringer; Amir Sharafkhaneh; Charlie Lan; Christine Wendt; Brian Bell; Ken M. Kunisaki; Eric L. Flenaugh; Hirut Gebrekristos; Mario Ponce; Silanath Terpenning; Gloria Westney; Russell Bowler; David A. Lynch; Richard Rosiello; David Pace; Gerard Criner; David Ciccolella; Francis Cordova; Chandra Dass; Gilbert D'Alonzo; Parag Desai; Michael Jacobs; Steven Kelsen; Victor Kim; A. James Mamary; Nathaniel Marchetti; Aditi Satti; Kartik Shenoy; Robert M. Steiner; Alex Swift; Irene Swift; Maria Elena Vega-Sanchez; Mark Dransfield; William Bailey; Surya P. Bhatt; Anand Iyer; Hrudaya Nath; J. Michael Wells; Douglas Conrad; Xavier Soler; Andrew Yen; Alejandro P. Comellas; Karin F. Hoth; John Newell; Brad Thompson; MeiLan K. Han; Ella Kazerooni; Wassim Labaki; Craig Galban; Dharshan Vummidi; Joanne Billings; Abbie Begnaud; Tadashi Allen; Frank Sciurba; Jessica Bon; Divay Chandra; Joel Weissfeld; Antonio Anzueto; Sandra Adams; Diego Maselli-Caceres; Mario E. Ruiz; Harjinder Singh
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)