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Relationships Between Thermal Dose and Heat-induced Tissue and Vascular Damage After Thermoradiotherapy of Locally Advanced Breast Carcinoma by H. Lyngt; O. R. Monge; P. J. Bøhler; E. K. Rofstad is a Medicine article available to read on EtoBox.

What is Relationships Between Thermal Dose and Heat-induced Tissue and Vascular Damage After Thermoradiotherapy of Locally Advanced Breast Carcinoma about?

Twenty-four patients with locally advanced breast carcinoma were given thermoradiotherapy, and heat-induced damage to tissue and vasculature was studied in relation to thermal dose. Thermometry was performed using six to eight multi-point thermistor probes. Heat-induced damage was quantified by histopathological analysis of biopsies taken from the temperature probe locations shortly after treatment. Both tumour and normal tissue were found in the biopsies. Fraction of tissue and fraction of vessels with heat-induced damage were determined for the malignant and the normal tissue compartment separately, using stereological techniques. Clear relationships were found between these parameters and the largest thermal dose achieved in one heat fraction. The data were subjected to logit analysis, and the thermal doses (eqv. min at 43°C) that caused massive necrosis in 50% of the tissue were calculated to be 1 1 6 f 3 1 for the malignant tissue compartment and 205 f 49 for the normal tissue compartment. Similarly, the thermal doses that caused damage to 50% of the vessels were found to be 63\*34 and 1 4 4 f 4 6 for the malignant and the normal tissue compartment, respectively. Thus, the tum

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Author

H. Lyngt; O. R. Monge; P. J. Bøhler; E. K. Rofstad

Published

1991

Language

EN

Field

Medicine (Health Sciences)