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Failure Patterns and Outcomes of Dose Escalation of Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer: a Multicenter Cohort Study by Xiaofei Zhu; Yangsen Cao; Tingshi Su; Xixu Zhu; Xiaoping Ju; Xianzhi Zhao; Lingong Jiang; Yusheng Ye; Fei Cao; Shuiwang Qing; Huojun Zhang is a Medicine article available to read on EtoBox.

What is Failure Patterns and Outcomes of Dose Escalation of Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer: a Multicenter Cohort Study about?

Objective: This study aims to compare recurrence patterns and outcomes of biologically effective dose (BED 10 , α/β = 10) of 60-70 Gy with those of a BED 10 >70 Gy for locally advanced pancreatic cancer (LAPC). Methods: Patients from three centers with a biopsy and a radiographically proven LAPC were retrospectively included and data were prospectively collected from June 2012 to June 2019. Radiotherapy was delivered by stereotactic body radiation therapy. Recurrences were categorized as in-field, marginal, and outside-the-field recurrence. Patients in two groups were required to receive abdominal enhanced contrast CT or MRI every 2-3 months and CA19-9 examinations every month during follow-up. Treatment-related toxicities were evaluated every month. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method. Results: After propensity score matching, there were 486 patients in each group. The median prescription dose of the two groups was 37 Gy/5-8 f (range: 36-40.8 Gy/5-8 f) and 42 Gy/5-8 f (range: 40-49.6 Gy/5-8 f), respectively. The median OS of patients with a BED 10 >70 Gy and a BED 10 60-70 Gy was 20.3 months (95% CI: 19.1-21.5 mont

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Author

Xiaofei Zhu; Yangsen Cao; Tingshi Su; Xixu Zhu; Xiaoping Ju; Xianzhi Zhao; Lingong Jiang; Yusheng Ye; Fei Cao; Shuiwang Qing; Huojun Zhang

Publisher

SAGE Publications

Published

2020

Language

EN

Field

Medicine (Health Sciences)